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2025-12-22 10:06:41 -

Pathophysiology of GH Hypersecretion and IGF-1 Mediation

Acromegaly is a chronic, progressive metabolic disorder primarily caused by the hypersecretion of Growth Hormone (GH) from the anterior pituitary gland. In over 95% of cases, this is due to a benign monoclonal pituitary adenoma—specifically a somatotroph adenoma. Unlike gigantism, which occurs before the closure of the epiphyseal plates in children, acromegaly occurs in adults and leads...

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